Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Two major enteric glial classes were identified in the pediatric intestine, highlighting the significant postnatal contribution of Schwann-like enteric glia to glial heterogeneity. Crucially, these glial subtypes persist in aganglionic segments of patients with HSCR, offering a new target for their treatment using 5-HT agonists.

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Publication Details

Journal
Gastroenterology
Published
2024-12-24
DOI
https://doi.org/10.1053/j.gastro.2024.12.011
Citations
25
Primary Topic
Congenital gastrointestinal and neural anomalies
Type
article
Field-Weighted Citation Impact
14.32

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article

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Jonathan D. Windster, Naomi Kakiailatu, Joke Zink, Katherine C. MacKenzie et al.
25 citations
Gastroenterology
Congenital gastrointestinal and neural anomalies
14.32
article

Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease

Jonathan D. Windster, Naomi Kakiailatu, Joke Zink, Katherine C. MacKenzie, Soheil Yousefi, Werend Boesmans, Agne Antanaviciute, Thierry van den Bosch, Robert M.W. Hofstra, Tahsin Stefan Barakat, Conny Meeussen, Emma de Pater, Andrea Sacchetti, Rene M. H. Wijnen, Kaushal Parikh, Maria M. Alves, Eric M. Bindels, Tsung Wai Kan, Veerle Melotte, Laura E. Kuil, Michail Doukas, Cornelius E. J. Sloots, Anthony Simmons
article en
25 citations

Abstract

Two major enteric glial classes were identified in the pediatric intestine, highlighting the significant postnatal contribution of Schwann-like enteric glia to glial heterogeneity. Crucially, these glial subtypes persist in aganglionic segments of patients with HSCR, offering a new target for their treatment using 5-HT agonists.

GastroenterologyVol. 168(5)
Erasmus MC (NL), John Radcliffe Hospital (GB), University of Oxford (GB), MRC Weatherall Institute of Molecular Medicine (GB), MRC Human Immunology Unit (GB), Erasmus MC Cancer Institute (NL), Medical Research Council (GB)
Medical Research Council
Zero hunger
Openalex Percentile: Top 1%
Congenital gastrointestinal and neural anomalies
14.32
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