Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease
Two major enteric glial classes were identified in the pediatric intestine, highlighting the significant postnatal contribution of Schwann-like enteric glia to glial heterogeneity. Crucially, these glial subtypes persist in aganglionic segments of patients with HSCR, offering a new target for their treatment using 5-HT agonists.
Authors
- Jonathan D. Windster (ORCID: https://orcid.org/0000-0001-9300-0234)
- Naomi Kakiailatu (ORCID: https://orcid.org/0009-0007-5513-1496)
- Joke Zink (ORCID: https://orcid.org/0000-0001-6829-244X)
- Katherine C. MacKenzie (ORCID: https://orcid.org/0000-0002-9656-637X)
- Soheil Yousefi (ORCID: https://orcid.org/0000-0001-6315-2544)
- Werend Boesmans (ORCID: https://orcid.org/0000-0002-2426-0451)
- Agne Antanaviciute (ORCID: https://orcid.org/0000-0002-9019-2215)
- Thierry van den Bosch (ORCID: https://orcid.org/0000-0002-7223-4565)
- Robert M.W. Hofstra (ORCID: https://orcid.org/0000-0001-7498-3829)
- Tahsin Stefan Barakat (ORCID: https://orcid.org/0000-0003-1231-1562)
- Conny Meeussen (ORCID: https://orcid.org/0009-0009-7672-894X)
- Emma de Pater (ORCID: https://orcid.org/0000-0002-7195-6769)
- Andrea Sacchetti (ORCID: https://orcid.org/0000-0001-9319-2205)
- Rene M. H. Wijnen (ORCID: https://orcid.org/0000-0001-7266-9713)
- Kaushal Parikh (ORCID: https://orcid.org/0000-0002-3247-3676)
- Maria M. Alves (ORCID: https://orcid.org/0000-0003-0083-5318)
- Eric M. Bindels (ORCID: https://orcid.org/0000-0001-9502-669X)
- Tsung Wai Kan (ORCID: https://orcid.org/0009-0001-0013-8486)
- Veerle Melotte (ORCID: https://orcid.org/0000-0002-9459-123X)
- Laura E. Kuil (ORCID: https://orcid.org/0000-0003-3330-1371)
- Michail Doukas (ORCID: https://orcid.org/0000-0002-8611-840X)
- Cornelius E. J. Sloots (ORCID: https://orcid.org/0000-0003-4466-3589)
- Anthony Simmons
Institutions
- Erasmus MC (NL)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- MRC Weatherall Institute of Molecular Medicine (GB)
- MRC Human Immunology Unit (GB)
- Erasmus MC Cancer Institute (NL)
- Medical Research Council (GB)
Publication Details
- Journal
- Gastroenterology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1053/j.gastro.2024.12.011
- Citations
- 25
- Primary Topic
- Congenital gastrointestinal and neural anomalies
- Type
- article
- Field-Weighted Citation Impact
- 14.32
Funders
- Medical Research Council