Risperidone-Induced Hypothermia in a Cerebral Palsy Patient: A Case Report and Literature Review

Cerebral palsy (CP) is a debilitating disorder that can lead to life-long disability, with a high incidence in Saudi Arabia. Secondary epilepsy and cardiac complications are common in CP patients. We present a rare case of a 17-year-old female with CP, attention-deficit hyperactivity disorder (ADHD), secondary epilepsy, and a history of post-cardiac arrest, with home medications carbamazepine, risperidone, and sodium valproate. The patient presented with behavioral changes, bradycardia, hypothermia, and hypotension. The patient experienced a generalized tonic-clonic seizure, which was treated. Despite initial interventions, bradycardia and hypothermia persisted. Cardiology evaluation revealed normal cardiac function. Risperidone was temporarily replaced with clonazepam and hydrocortisone, resulting in the patient's arousal and stable vital signs. During the course of hospitalization, the patient also developed watery diarrhea, which was resolved after stopping antibiotics on the sixth day. The patient was discharged after 13 days with stable vital signs and follow-up instructions. This case highlights the complexity of managing CP patients with multiple comorbidities and the importance of a multidisciplinary approach to their care. It also underscores the urgent need for further research to improve the understanding of CP and its associated complications and develop more effective management strategies.