STANDARDIZATION OF ANTIULCER HERBAL REMEDY

Introduction. The herbal remedy intended for the treatment and prevention of gastric and duodenal ulcers includes dry extracts of 8 plants and finely сrushed powder of coriander fruit. Determining the quality indicators of the herbal remedy and its components – dry extracts – is the purpose of this work. Materials and methods. Dry extracts for the preparation of herbal remedy were obtained from the Small Innovative Enterprise "Arura" (Ulan-Ude). Qualitative and quantitative analysis of phenolic compounds and glycyrrhizic acid was determined by HPLC. The total contents of sum of biologically active substances were determined using pharmacopoeial methods. Results. Cynaroside, lycurazide, narcissin, typhaneoside, rutin, isoquercitrin, dihydroquercetin, catechin, epigallocatechin gallate, coumarin, gallic, chlorogenic, chicoric, caffeic, ferulic, and glycyrrhizic acids were identified by HPLC in the herbal remedy. Conclusion. The quality indicators of the herbal remedy include the recommended content of biologically active substances: the sum of flavonoids in terms of rutin – no less than 2.0%, glycyrrhizic acid – no less than 0.1% (HPLC), ascorbic acid – no less than 0.3%. The UV spectrum of a 70% alco-holic extract of the herbal remedy should have a maximum absorption at a wavelength of 230–236 nm, 330±5 nm, 273 sh., a minimum absorption at 312, 216 nm.