POLYPROGMASIA INFLUENCE ON THE DEVELOPMENT OF COMPLICATIONS IN ELDERLY AND SENILE PEOPLE WITH LOW CREATININE CLEARANCE

Introduction. This paper highlights the issues of polypragmasia and its impact on clinical outcomes of oral anticoagulants. Objective. To report the clinical outcomes of oral anticoagulants in patients with polypragmasia. Material and methods. 503 patients taking oral anticoagulants along with other drugs were included in the study. Results. according to the results of the study it was found that polypragmasia is a significant factor of POAC-related complications. The factors of drug withdrawal or complications related to POAC administration were: obesity of 2nd and 3rd degree, advanced age, chronic kidney disease stage C3b and C4. The above factors are the direct factors of polypragmasy, which in itself reduces adherence to POAC, in addition to that POAC withdrawal was found to be associated with the patient's intake of a number of drugs. Conclusion. polypragmasy has a negative impact on POAC intake. On the one hand it is a factor of decreased adherence to treatment, on the other hand - a factor of undesirable drug interactions.