BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI
In this study, we introduce a new method to study the coupling of CSF flow measured in the fourth ventricle to cortical BOLD fluctuations. In contrast to the original approach, the use of phase contrast MRI to measure CSF flow provides a quantitative in- and outflow curve, and improved BOLD-CSF coupling metrics.
Authors
- Emiel Roefs (ORCID: https://orcid.org/0000-0003-4150-9826)
- Jeroen de Bresser (ORCID: https://orcid.org/0000-0003-0759-8407)
- Matthias J.P. van Osch (ORCID: https://orcid.org/0000-0001-7034-8959)
- Lydiane Hirschler (ORCID: https://orcid.org/0000-0003-2379-0861)
- Ingmar Eiling (ORCID: https://orcid.org/0000-0002-0229-663X)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s12987-024-00607-8
- Citations
- 10
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 2.68
Funders
- EU Joint Programme – Neurodegenerative Disease Research
- Fondation Leducq
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland