Recombinant Anti-PF4 Antibodies Derived from Patients with Vaccine-Induced Immune Thrombocytopenia and Thrombosis (VITT) Facilitate Research and Laboratory Diagnosis of VITT
The six rAbs derived from VITT patients reflect VITT-typical binding capacities and the ability to activate platelets. Therefore, these rAbs offer an attractive new option to study VITT pathophysiology.
Authors
- Thomas Thiele (ORCID: https://orcid.org/0000-0003-0177-6508)
- Luisa Müller (ORCID: https://orcid.org/0000-0001-7942-3273)
- Lucy Rutten (ORCID: https://orcid.org/0000-0002-7363-6822)
- Roland Zahn (ORCID: https://orcid.org/0000-0003-2822-6231)
- Marta Broto (ORCID: https://orcid.org/0000-0002-4524-4290)
- Olga Esteban (ORCID: https://orcid.org/0009-0006-1846-4526)
- Stefan Handtke (ORCID: https://orcid.org/0000-0002-7331-8998)
- Linda Schönborn (ORCID: https://orcid.org/0000-0002-6660-9949)
- Marta Palicio (ORCID: https://orcid.org/0000-0001-6173-6730)
- Tom P. Gordon (ORCID: https://orcid.org/0000-0003-3232-8249)
- Venkata A. S. Dabbiru (ORCID: https://orcid.org/0000-0002-8140-4335)
- Andreas Greinacher (ORCID: https://orcid.org/0000-0001-8343-7336)
- Rinke Bos
- Jing Jing Wang (ORCID: https://orcid.org/0000-0003-0114-5570)
Institutions
- South Australia Pathology (AU)
- Flinders University (AU)
- Universitätsmedizin Greifswald (DE)
- Janssen (Netherlands) (NL)
- Werfen (Spain) (ES)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3390/vaccines13010003
- Citations
- 7
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- American Society of Hematology
- Else Kröner-Fresenius-Stiftung