Learning From Full Characterization of HIV Proviruses in People Receiving Long-Acting Cabotegravir/Rilpivirine With a History of Replication on the Antiretroviral Classes
Our findings highlight the difficulty in interpreting the clinical significance of DRMs when detected in proviral DNA and the need to filter out hypermutated sequences. Detected DRMs could be harbored by defective archived genomes unlikely to contribute to treatment failure.
Authors
- Antoine Chaillon (ORCID: https://orcid.org/0000-0001-9490-3857)
- Véronique Avettand-Fènoël (ORCID: https://orcid.org/0000-0002-7022-2990)
- Elise Gardiennet (ORCID: https://orcid.org/0000-0003-4654-142X)
- Gilbert Mchantaf (ORCID: https://orcid.org/0000-0002-2094-0492)
- Clémence Guillaume
- Thiérry Prazuck (ORCID: https://orcid.org/0000-0002-2212-6873)
- Alice‐Andrée Mariaggi (ORCID: https://orcid.org/0000-0002-1677-2967)
- Laurent Hocqueloux (ORCID: https://orcid.org/0000-0002-2264-4822)
- Caroline Charre (ORCID: https://orcid.org/0000-0002-4356-5146)
- Adeline Mélard (ORCID: https://orcid.org/0000-0003-1207-0201)
- Julie Bois (ORCID: https://orcid.org/0000-0003-1410-8250)
- Jérôme Guinard
Institutions
- Université d'Orléans (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- University of California System (US)
- University of California San Diego (US)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut Cochin (FR)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/ofid/ofae748
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gilead Sciences
- ViiV Healthcare