Identifying a Genetic Link Between Lung Function and Psoriasis
This study has unveiled genetic variants that bridge the realms of psoriasis and lung function. The genes associated with these variants, including IFIH1, Grancalcin gene (GCA), and NFKB inhibitor alpha gene (NFKBIA), regulate innate immune responses, which suggests that immunodysregulation, a central element in psoriasis pathogenesis, may also impact lung function, alluding to a "skin-lung axis."
Authors
- Melinda C. Aldrich (ORCID: https://orcid.org/0000-0003-3833-8448)
- Jinchuan Xing (ORCID: https://orcid.org/0000-0001-6469-8733)
- James Jaworski (ORCID: https://orcid.org/0009-0009-2852-4088)
- Divay Chandra (ORCID: https://orcid.org/0009-0009-5555-4645)
- Satoshi Okawa (ORCID: https://orcid.org/0000-0003-3916-3109)
- Kazuya Tanimura (ORCID: https://orcid.org/0000-0002-3406-9394)
- Toru Nyunoya (ORCID: https://orcid.org/0000-0002-0688-4607)
- Mehdi syed Nouraie (ORCID: https://orcid.org/0000-0001-7465-0581)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Pittsburgh (US)
- VA Pittsburgh Healthcare System (US)
- Nara Medical University (JP)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Annals of Human Genetics
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1111/ahg.12587
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.24
Funders
- U.S. Department of Veterans Affairs
- American Heart Association
- Office of Research and Development
- Vanderbilt University
- Vanderbilt University Medical Center
- Georgia Clinical and Translational Science Alliance
- National Institutes of Health
- National Heart, Lung, and Blood Institute