The effects of saturated and unsaturated fatty acids on MASLD: a Mendelian randomization analysis and in vivo experiment
SFA and PUFA did not have a significant causal effect on MASLD, but MUFA intake is a risk factor for MASLD. A MUFA-enriched diet increased the incidence of macrovesicular steatosis and the hepatic triglyceride levels. Therefore, replacing MUFA intake with a moderate intake of PUFA might help reduce the risk of MASLD.
Authors
- Fengming Xu (ORCID: https://orcid.org/0000-0002-6523-804X)
- Mohamed Albadry (ORCID: https://orcid.org/0000-0002-6192-8713)
- Annika Döding
- Uta Dahmen (ORCID: https://orcid.org/0000-0003-3483-3388)
- Ulrike Schulze‐Späte (ORCID: https://orcid.org/0000-0002-8046-0394)
- Xinpei Chen
- Olaf Dirsch (ORCID: https://orcid.org/0000-0003-2791-2061)
Institutions
- Zhejiang Chinese Medical University (CN)
- Vivantes Klinikum (DE)
- Jena University Hospital (DE)
- Menoufia University (EG)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1007/s00394-024-03560-2
- Citations
- 8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.09
Funders
- Universitätsklinikum Jena