Esophageal microbial dysbiosis impairs mucosal barrier integrity via toll-like receptor 2 pathway in patients with gastroesophageal reflux symptoms
This study demonstrated that regardless of objective evidence of reflux, patients with GER symptoms presented esophageal microbial dysbiosis characterized by an elevated proportion of Gram-negative bacteria. Enriched Gram-negative bacteria could induce esophageal barrier dysfunction via LPS-TLR2-IL-6-claudin-1-DIS pathway.
Authors
- Xingyu Jia (ORCID: https://orcid.org/0000-0003-0096-9404)
- Qianjun Zhuang (ORCID: https://orcid.org/0000-0002-7902-291X)
- Niandi Tan (ORCID: https://orcid.org/0000-0002-6456-7482)
- Songfeng Chen (ORCID: https://orcid.org/0000-0002-6448-0395)
- Dianxuan Jiang (ORCID: https://orcid.org/0009-0003-7816-8110)
- Mengyu Zhang (ORCID: https://orcid.org/0000-0002-2838-1103)
- Huiting Lin (ORCID: https://orcid.org/0009-0004-5399-8924)
- Yinglian Xiao (ORCID: https://orcid.org/0000-0002-4278-8583)
- Jing Chen (ORCID: https://orcid.org/0009-0001-6510-1211)
- Xun Hou
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s12967-024-05878-1
- Citations
- 9
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Natural Science Foundation of China