Effects of a Tailored Home-Based Exercise Program, “KidMove”, on Children with Cystic Fibrosis: A Quasi-Experimental Study

<b>Background/Objectives:</b> Exercise for children with cystic fibrosis leads to well-known health benefits. However, maintaining regular activity is challenging due to the daily demands of academics, clinical care, and family tasks. Home-based exercise programs offer a more adaptable alternative, fitting into family schedules. This study evaluated the effectiveness of the "KidMove" program, a parent-supervised, tailored, home exercise regimen. <b>Methods:</b> A quasi-experimental study was conducted with an intervention group (IG) and a wait-list control group (CG). The "KidMove" program lasted 12 weeks and included 35 exercises targeting endurance, resistance, flexibility, and neuromotor training. The primary outcome, endurance, was measured with the Modified Shuttle Walking Test, while secondary outcomes included body composition, resistance, flexibility, postural control, respiratory function, and health-related quality of life. Data were collected at baseline and post-intervention. A per-protocol analysis was conducted with generalized estimating equations (GEEs). <b>Results:</b> Forty-six children aged 10 ± 4 years (6 to 18 years), mostly male (n = 24; 52.2%), participated. Significant improvements were observed in the Modified Shuttle Walking Test [Wald χ² = 14.24, <i>p</i> < 0.001], postural control [Wald χ² = 3.89, <i>p</i> = 0.048], knee flexibility [Wald χ² = 5.58, <i>p</i> = 0.018], and emotional functioning [Wald χ² = 9.34, <i>p</i> = 0.002] categories. <b>Conclusions:</b> The "KidMove" program offers a practical, family friendly alternative to center-based exercise by empowering parents to support their children's physical activity at home, endurance, flexibility, and emotional well-being, while reducing the logistical challenges.