Aerobic exercise inhibits GSDME-dependent myocardial cell pyroptosis to protect ischemia-reperfusion injury
In conclusion, our study highlights the role of IGFBP2 in mitigating GSDME-dependent pyroptosis as a mechanism through which aerobic exercise exerts cardioprotective effects against IR injury. These insights suggest potential therapeutic targets for managing acute myocardial infarction.
Authors
- Chenxi Xia (ORCID: https://orcid.org/0000-0003-1036-4222)
- Xuyang Meng
- Xiang Wang (ORCID: https://orcid.org/0000-0002-8215-4390)
- Yi Li (ORCID: https://orcid.org/0000-0002-6819-2462)
- Jun Wang (ORCID: https://orcid.org/0000-0002-8254-7610)
- Jiefu Yang
- Chenguang Yang (ORCID: https://orcid.org/0000-0001-7218-2040)
- Fang Wang (ORCID: https://orcid.org/0000-0002-6878-5495)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s10020-024-01048-7
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China