IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced vascular permeability
Our results indicate that early administration of MSCp significantly reduced the percentage of water content and EB dye in the liver but not in the kidney. These results were associated with a trend toward decreased plasma levels of Syndecan-1, ICAM-1, vWF, and VCAM-1. In vitro, MSCp reduced leukocyte-endothelial cell adhesion. Together, our results suggest that MSCp help to prevent endothelial dysfunction and vascular leakage, which, in turn, could protect the liver from injury.
Authors
- Juliette Peltzer (ORCID: https://orcid.org/0000-0002-4742-7912)
- Nathalie Baudry
- Aurélie Campeanu
- Sébastien Banzet (ORCID: https://orcid.org/0000-0003-0785-0019)
- Marion Grosbot
- Éric Vicaut (ORCID: https://orcid.org/0000-0001-6303-8557)
- Caroline Doutrelon
- Clotilde Aussel
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Hôpital d'instruction des Armées Percy (FR)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s12967-024-05961-7
- Citations
- 2
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Ministère des Armées