Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice
Engineering the MERS-CoV spike protein is crucial for its successful display on NDV particles. The strong immune responses elicited by the NDV-S<sub>MERS</sub> vaccine in mice highlight that NDV is a promising, safe, and effective platform for MERS-CoV vaccination.
Authors
- Challika Kaewborisuth (ORCID: https://orcid.org/0000-0003-3477-3784)
- Jarin Kramyu
- Kanjana Srisutthisamphan
- Nanchaya Wanasen
- Payuda Hansoongnern (ORCID: https://orcid.org/0000-0001-9239-6708)
- Jaturawitt Prasopsiri
- Papon Muangsanit (ORCID: https://orcid.org/0000-0003-0595-982X)
- Anan Jongkaewwattana (ORCID: https://orcid.org/0000-0003-2354-9883)
- Benjamas Liwnaree
- Nathiphat Tanwattana
- Suttipun Sungsuwan (ORCID: https://orcid.org/0000-0001-9472-4672)
- Juggragarn Jengarn (ORCID: https://orcid.org/0000-0003-2443-3727)
Institutions
- National Science and Technology Development Agency (TH)
- National Center for Genetic Engineering and Biotechnology (TH)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-24
- DOI
- https://doi.org/10.3390/vaccines13010002
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Development Agency
- National Center for Genetic Engineering and Biotechnology