Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer’s, and liver cancer
The NCSTN knockout mouse might be employed as HS animal model; Reducing nicastrin may affect the expression of notch1-hes1 pathway molecules in skin, brain, and liver tissues; low dose (10 mg/kg/d) tamoxifen could be used to induce the deletion of the target gene in mice.
Authors
- H. Liu
- Zhihui Dong (ORCID: https://orcid.org/0000-0002-3754-2458)
- Tian‐Wei Shi
- Lin Zhu
- Zhenpeng Shi
- Jianguo Li (ORCID: https://orcid.org/0000-0001-8178-7965)
- Yan Lu (ORCID: https://orcid.org/0000-0002-8370-4059)
- Haiming Yu (ORCID: https://orcid.org/0000-0002-8230-183X)
- Jian Zhou
- Ting Long (ORCID: https://orcid.org/0000-0002-9108-4873)
- Yinsen Song
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
Institutions
- Zhengzhou University (CN)
- Nanfang Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Henan Cancer Hospital (CN)
- Zhengzhou People's Hospital (CN)
- Southern Medical University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s40001-024-02225-4
- Citations
- 1
- Primary Topic
- Hidradenitis Suppurativa and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.53
Funders
- National Natural Science Foundation of China