Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway
EA activates AMPK through CB2R, enhancing β-END expression in inflamed skin to alleviate inflammatory pain. This study reveals a new link between endocannabinoids, endorphins, and AMPK in analgesic effects of EA, highlighting the CB2R-AMPK-β-END pathway.
Authors
- Yuming Wu (ORCID: https://orcid.org/0000-0002-3282-056X)
- Tengfei Hou
- Ke Zhang (ORCID: https://orcid.org/0000-0002-0327-9129)
- Ming Zhao (ORCID: https://orcid.org/0000-0002-7539-3887)
- Xiao Yuan (ORCID: https://orcid.org/0000-0003-3590-1805)
- Kaichen Wang (ORCID: https://orcid.org/0000-0002-0845-5291)
- Jiahao Xu (ORCID: https://orcid.org/0000-0001-8311-2793)
- Xiang‐Hong Jing (ORCID: https://orcid.org/0000-0003-0272-1576)
- Yuye Lan (ORCID: https://orcid.org/0000-0001-7355-2066)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-0934-4155)
- Ziyu Zhou (ORCID: https://orcid.org/0000-0001-7565-9414)
- Xuefei Hu (ORCID: https://orcid.org/0000-0002-1840-7787)
- Renjie Qin
- Hui‐Lin Pan (ORCID: https://orcid.org/0000-0001-8444-3770)
- Man Li (ORCID: https://orcid.org/0000-0003-4041-0437)
- Hong Zhang (ORCID: https://orcid.org/0009-0007-0831-9162)
- Zixiao Wang (ORCID: https://orcid.org/0000-0003-2627-6630)
- Yongmin Liu (ORCID: https://orcid.org/0000-0002-1180-902X)
- Yunqing Rao (ORCID: https://orcid.org/0000-0003-2191-3338)
- Jingjing Sun
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jianghan University (CN)
- Hubei University of Science and Technology (CN)
- China Academy of Chinese Medical Sciences (CN)
- China Association of Acupuncture-Moxibustion (CN)
- Huazhong University of Science and Technology (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s13020-024-01048-z
- Citations
- 14
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- National Natural Science Foundation of China
- Key Program of NSFC-Tongyong Union Foundation