Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway

EA activates AMPK through CB2R, enhancing β-END expression in inflamed skin to alleviate inflammatory pain. This study reveals a new link between endocannabinoids, endorphins, and AMPK in analgesic effects of EA, highlighting the CB2R-AMPK-β-END pathway.

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Publication Details

Journal
Chinese Medicine
Published
2024-12-24
DOI
https://doi.org/10.1186/s13020-024-01048-z
Citations
14
Primary Topic
Acupuncture Treatment Research Studies
Type
article
Field-Weighted Citation Impact
10.03

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article

Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway

Yuming Wu, Tengfei Hou, Ke Zhang, Ming Zhao et al.
14 citations
Chinese Medicine
Acupuncture Treatment Research Studies
10.03
article

Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway

Yuming Wu, Tengfei Hou, Ke Zhang, Ming Zhao, Xiao Yuan, Kaichen Wang, Jiahao Xu, Xiang‐Hong Jing, Yuye Lan, Xinyue Liu, Ziyu Zhou, Xuefei Hu, Renjie Qin, Hui‐Lin Pan, Man Li, Hong Zhang, Zixiao Wang, Yongmin Liu, Yunqing Rao, Jingjing Sun
article en
14 citations

Abstract

EA activates AMPK through CB2R, enhancing β-END expression in inflamed skin to alleviate inflammatory pain. This study reveals a new link between endocannabinoids, endorphins, and AMPK in analgesic effects of EA, highlighting the CB2R-AMPK-β-END pathway.

Chinese MedicineVol. 19(1)
The University of Texas MD Anderson Cancer Center (US), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Jianghan University (CN), Hubei University of Science and Technology (CN), China Academy of Chinese Medical Sciences (CN), China Association of Acupuncture-Moxibustion (CN), Huazhong University of Science and Technology (CN), Xi'an Jiaotong University (CN)
National Natural Science Foundation of China, Key Program of NSFC-Tongyong Union Foundation
Affordable and clean energy
Openalex Percentile: Top 2%
Acupuncture Treatment Research Studies
10.03
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