Nerve regeneration using a Bio 3D conduit derived from umbilical cord–Derived mesenchymal stem cells in a rat sciatic nerve defect model
The Bio 3D conduit prepared from UC-MSCs was superior to the silicone tube and achieved comparable nerve regeneration to the autologous (autograft) group. Rejection was suppressed in the Bio 3D group compared to the allograft group. Although this study used a xenograft model, we speculate that rejection was low due to the characteristics of UC-MSCs. UC-MSCs are a useful cell source for Bio 3D conduits.
Authors
- Daichi Sakamoto (ORCID: https://orcid.org/0000-0003-4684-6653)
- Fumitaka Nagamura (ORCID: https://orcid.org/0000-0002-5742-0343)
- Koichi Nakayama (ORCID: https://orcid.org/0000-0002-7324-8862)
- Yudai Miyazaki
- Koichi Yoshimoto (ORCID: https://orcid.org/0009-0004-2397-2766)
- Tomoki Aoyama (ORCID: https://orcid.org/0000-0003-3512-054X)
- Terunobu Iwai
- Tokiko Nagamura‐Inoue (ORCID: https://orcid.org/0000-0002-6556-2894)
- Kazuaki Fujita
- Shizuka Akieda
- Ryosuke Ikeguchi (ORCID: https://orcid.org/0000-0003-4525-7849)
- Takashi Noguchi (ORCID: https://orcid.org/0000-0003-2965-4772)
- Shuichi Matsuda (ORCID: https://orcid.org/0000-0003-0802-1255)
Institutions
- Saga University (JP)
- Kyoto University (JP)
- University of Tokyo Hospital (JP)
- Kyoto University Hospital (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1371/journal.pone.0310711
- Citations
- 4
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Japan Agency for Medical Research and Development