Peptide Nanocarriers for Targeted Delivery of Nucleic Acids for Cancer Therapy
Peptides have been extensively studied in nanomedicine with great bioactivity and biocompatibility; however, their poor cell-membrane-penetrating properties and nonselectivity greatly limit their clinical applications. In this study, tumor-targeting therapy was achieved by modifying our previously developed efficient peptide vector with the cancer-targeting peptide RGD, enabling it to specifically target tumor cells with a high expression of RGD-binding receptors. B-cell lymphoma-2 antisense oligonucleotides were selected as the target model to validate the effectiveness of the delivery carriers. Results demonstrated that this delivery system can be efficiently and selectively taken up by RGD receptor-positive cells (α<sub>v</sub>β<sub>3</sub> integrin receptor), further inducing effective target gene knockdown. Overall, this system provided a promising strategy for the targeted delivery of nucleic acid drugs.
Authors
- Leying Jiang
- Dongyuan Wang (ORCID: https://orcid.org/0000-0002-6045-0703)
- Xinrui Sha
- Yaping Zhang (ORCID: https://orcid.org/0000-0002-2819-6397)
- Lixiang Zhang
- Zijun Jiao
- Xinyu Li (ORCID: https://orcid.org/0000-0003-4388-4240)
- Xi Li (ORCID: https://orcid.org/0009-0008-4480-8251)
- Zigang Li (ORCID: https://orcid.org/0000-0002-4649-1592)
- Feng Yin (ORCID: https://orcid.org/0000-0001-7407-9047)
- Zhi-Yong Yao (ORCID: https://orcid.org/0000-0002-5553-5171)
- Chunli Song (ORCID: https://orcid.org/0000-0003-0642-3680)
- Yun Xing (ORCID: https://orcid.org/0009-0003-2442-2064)
Institutions
- Union Hospital (HK)
- Peking University (CN)
- Shenzhen Bay Laboratory (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1021/acs.bioconjchem.4c00324
- Citations
- 5
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Science and Technology Foundation of Shenzhen City
- Natural Science Foundation of Guangdong Province
- Shenzhen-Hong Kong Institute of Brain Science
- Shenzhen Bay Laboratory
- National Key Research and Development Program of China
- Beijing National Laboratory for Molecular Sciences