Disrupting heroin-associated memory reconsolidation through actin polymerization inhibition in the nucleus accumbens core
Inhibiting actin polymerization during the reconsolidation window disrupts heroin-associated memory reconsolidation, leading to decreased heroin-seeking behavior and prevention of relapse. These effects are contingent upon the presence of a retrieval trial and exhibit temporal specificity, shedding light on addiction mechanisms and potential therapeutic interventions.
Authors
- Yiwei Liao (ORCID: https://orcid.org/0000-0002-7860-8337)
- Haoyu Li (ORCID: https://orcid.org/0000-0002-0722-6809)
- Jiaxin Chen (ORCID: https://orcid.org/0000-0003-0373-984X)
- Meng Li (ORCID: https://orcid.org/0000-0002-0145-5440)
- Xin Mo
- Haiting Zhao
- Peng Du
- Mengqi Gong
Institutions
- Central South University (CN)
- Xinjiang Medical University (CN)
- National Clinical Research (US)
- Xiangya Hospital Central South University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1093/ijnp/pyae065
- Citations
- 1
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- National Natural Science Foundation of China