α‐Synuclein Gene Hypomethylation in <scp>LRRK2</scp> Parkinson's Disease Patients
This study shows for the first time that SNCA hypomethylation occurs in patients with L2PD. Further studies addressing SNCA methylation status in additional worldwide LRRK2 cohorts are warranted. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Alícia Garrido (ORCID: https://orcid.org/0000-0003-0652-6348)
- Mario Ezquerra (ORCID: https://orcid.org/0000-0003-3246-6641)
- Daniel F. Pilco‐Janeta (ORCID: https://orcid.org/0000-0003-3640-0498)
- Francesc Valldeoriola (ORCID: https://orcid.org/0000-0002-8680-4274)
- J. Pérez Pérez (ORCID: https://orcid.org/0000-0003-3961-1565)
- Manel Fernández (ORCID: https://orcid.org/0000-0002-8558-9920)
- Lorena de Mena (ORCID: https://orcid.org/0000-0001-7096-0611)
- Eduardo Tolosa (ORCID: https://orcid.org/0000-0002-3781-0854)
- Rubén Fernández‐Santiago (ORCID: https://orcid.org/0000-0002-4582-0702)
- Ana Cámara (ORCID: https://orcid.org/0000-0002-8005-9461)
- María‐José Martí (ORCID: https://orcid.org/0000-0002-9872-7835)
- Guillem Parés
Institutions
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Clínic de Barcelona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
Publication Details
- Journal
- Movement Disorders
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/mds.30094
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Eli Lilly and Company
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Universitat de Barcelona
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Instituto de Salud Carlos III