Siesta behavior and genetics interact to influence obesity risk
A total of 42.4% of the population usually took siesta. A significant genetic influence on siesta propensity was found, with a higher genetic predisposition linked to taking siesta more frequently (odds ratio [OR] = 1.17, 95% CI: 1.03-1.32; p = 0.015). Participants with a higher genetic propensity for siesta showed poorer dietary habits (p < 0.05). Among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have lower odds of having obesity (p = 0.038) compared with those who do not. Similarly, in exploratory analysis, among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have higher odds of weight-loss success (p = 0.007) compared with those who do not. CONCLUSIONS: Considering the ongoing debate regarding whether siesta is beneficial or detrimental, our findings suggest that individual genetic predisposition to siesta might influence the association between siesta and health.
Authors
- Aurora Aragón Alonso (ORCID: https://orcid.org/0000-0003-4507-9210)
- Ana Isabel Cascales (ORCID: https://orcid.org/0000-0002-2204-7534)
- Frank A. J. L. Scheer (ORCID: https://orcid.org/0000-0002-2014-7582)
- Richa Saxena (ORCID: https://orcid.org/0000-0003-2233-1065)
- Hassan S. Dashti (ORCID: https://orcid.org/0000-0002-1650-679X)
- Diego Salmerón (ORCID: https://orcid.org/0000-0002-4574-6880)
- María Rodríguez‐Martín (ORCID: https://orcid.org/0000-0002-9877-7728)
- Marta Garaulet (ORCID: https://orcid.org/0000-0002-4066-3509)
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Circadian (United States) (US)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Obesity
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/oby.24173
- Citations
- 2
- Primary Topic
- Obesity, Physical Activity, Diet
- Type
- article
- Field-Weighted Citation Impact
- 1.09
Funders
- Ministerio de Ciencia e Innovación
- National Institutes of Health
- Agencia Estatal de Investigación