The Significance of Detecting an Unusual Myeloblast Immunophenotype in a Presumptive Clinical Diagnosis of Myelodysplastic Syndromes
Our data show that if a presumptive MDS shows a nonprimitive blast phenotype, caution is needed to rule out AML with recurrent genetic abnormality with an oligoblastic presentation, high-risk myeloid neoplasms with double-hit TP53 mutation with abnormal erythroid proliferation, and MDS with molecular-genetic and clinical features more akin to AML.
Authors
- Leonard Jeffrey Medeiros (ORCID: https://orcid.org/0000-0001-6577-8006)
- Beenu Thakral (ORCID: https://orcid.org/0000-0001-5140-3633)
- Jeffrey L. Jorgensen (ORCID: https://orcid.org/0000-0002-1875-2986)
- Okechukwu Nwogbo
- Chi Young Ok (ORCID: https://orcid.org/0000-0002-6822-7880)
- Guilin Tang (ORCID: https://orcid.org/0000-0002-9482-4806)
- Sanam Loghavi (ORCID: https://orcid.org/0000-0001-8980-3202)
- Fuli Jia
- Fatima Zahra Jelloul (ORCID: https://orcid.org/0000-0002-3791-3204)
- Fnu Sameeta
- Sa A. Wang (ORCID: https://orcid.org/0000-0001-9385-9911)
- Jie Xu (ORCID: https://orcid.org/0000-0002-1897-1644)
- Shaoying Li (ORCID: https://orcid.org/0000-0002-6857-0523)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2024-12-23
- DOI
- https://doi.org/10.5858/arpa.2024-0228-oa
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00