Accelerated ovarian failure results in brain alterations related to Alzheimer's disease that are not recovered by high‐intensity interval training in mice
The menopausal decline in ovarian estrogen production increases the risk of Alzheimer's disease (AD). The chronological development of this connection is not well defined because of the lack of animal models that recapitulate the time course of menopause. 4-vinylcyclohexene diepoxide (VCD)-induced ovarian failure provides a model that simulates the average human experience in the transition from perimenopause to menopause. We demonstrate that cognitive and biochemical effects related to AD pathology are present from the earliest available timepoint in perimenopause in VCD mice. This work highlights the importance of examining the time course in the progression to menopause and the use of VCD as a model to investigate changes in the brain.
Authors
- Parastoo Mashouri
- Michael S. Finch (ORCID: https://orcid.org/0000-0002-6902-5885)
- M. Ayaz Ahmad (ORCID: https://orcid.org/0000-0002-5731-5439)
- Emma F. Hubbard
- Shawn M. Beaudette (ORCID: https://orcid.org/0000-0002-8427-3959)
- W. Glen Pyle (ORCID: https://orcid.org/0000-0003-0980-4729)
- Sarah Rouhana
- Siu Kwan Sze (ORCID: https://orcid.org/0000-0002-5652-1687)
- Rebecca E. K. MacPherson (ORCID: https://orcid.org/0000-0002-1577-2658)
- Geoffrey A. Power (ORCID: https://orcid.org/0000-0003-2604-0740)
- Ciara Barry
Institutions
- Dalhousie University (CA)
- Brock University (CA)
- Women's Health Research Institute (CA)
- University of Guelph (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14463
- Citations
- 1
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.36
Funders
- Heart and Stroke Foundation of Canada
- Natural Sciences and Engineering Research Council of Canada