Design of an anti-PD-L1-mediated MOF nanodrug delivery system using terpyridine-metal coordination for tumor theranostics
An anti-PD-L1 mediated nanodrug delivery system is developed by modifying the MOF surface and using Tpy-Gd<sup>3+</sup>-Tpy coordination chemistry, enabling the simultaneous delivery of chemotherapy and immunotherapy drugs. The platform enables regulated drug release and integrates multiple imaging modalities, promoting targeted delivery and facilitating tumor diagnosis through FL and MR imaging.
Authors
- Jia Chen (ORCID: https://orcid.org/0000-0001-5924-8674)
- Xu Han (ORCID: https://orcid.org/0000-0002-0238-543X)
- Shengwang Zhou (ORCID: https://orcid.org/0000-0003-1390-2460)
- Zhihao Cheng (ORCID: https://orcid.org/0000-0002-7172-5880)
Institutions
- Jiangsu University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1039/d4cc05933f
- Citations
- 4
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Natural Science Foundation of China
- Senior Talent Foundation of Jiangsu University