Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life
Premenopausal bilateral oophorectomy (PBO) before the ages of 46 (early PBO) years and ages 46 to 49 (late PBO) years was studied. Early PBO was associated with reduced entorhinal cortex thickness later in life. Early PBO was associated with greater amyloid beta (Aβ) load at older ages. Early PBO was associated with greater Alzheimer's disease pattern of atrophy at older ages. Early PBO was associated with higher tau load at higher Aβ levels.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- Anna Castillo (ORCID: https://orcid.org/0009-0004-2037-7646)
- Nathan K. LeBrasseur (ORCID: https://orcid.org/0000-0002-2002-0418)
- Evdokiya Knyazhanskaya (ORCID: https://orcid.org/0000-0003-3031-9808)
- Walter A. Rocca (ORCID: https://orcid.org/0000-0002-1832-7664)
- Kent R. Bailey (ORCID: https://orcid.org/0000-0001-8968-643X)
- Firat Kara
- Julie A. Fields (ORCID: https://orcid.org/0000-0002-1282-9866)
- Matthew L. Senjem (ORCID: https://orcid.org/0000-0001-9308-9275)
- Jennifer R. Geske (ORCID: https://orcid.org/0000-0002-7341-1535)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Ekta Kapoor (ORCID: https://orcid.org/0000-0003-3296-0500)
- Kejal Kantarci
- Christopher G. Schwarz
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14469
- Citations
- 5
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- Eli Lilly and Company
- National Institutes of Health
- Avid Radiopharmaceuticals
- National Institute on Aging