Association of tyrosine kinase 2 polymorphisms with susceptibility to microscopic polyangiitis in a Guangxi population
This study indicates that mutations in the TYK2 gene (rs2304256, rs280519, and rs12720270) may be associated with a reduced risk of MPA in the male Chinese population in Guangxi. The A allele of single nucleotide polymorphism (SNP) rs2304256 may be a protective factor against MPA, while the G alleles of SNPs rs280519 and rs12720270 are protective factors against MPA.
Authors
- Shurong Lu (ORCID: https://orcid.org/0000-0001-6730-4306)
- Fei Feng (ORCID: https://orcid.org/0009-0000-3217-0467)
- Liepeng Chu (ORCID: https://orcid.org/0000-0002-7243-6861)
- Chao Xue (ORCID: https://orcid.org/0000-0003-2888-9975)
- Bo Yang (ORCID: https://orcid.org/0000-0003-1218-9771)
Institutions
- Guangxi Medical University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2024-12-23
- DOI
- https://doi.org/10.7717/peerj.18735
- Citations
- 2
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Natural Science Foundation of Guangxi Province
- Guangxi Medical University