Life's Essential 8 and midlife trajectories in cognition and brain health: The CARDIA study
Poor cardiovascular health in early midlife is associated with faster decline in cognition across 10 years overall and in specific domains. Poor and intermediate cardiovascular health was associated with higher accumulation of white matter hyperintensities across midlife. Poor cardiovascular health was associated with faster atrophy in total gray matter volume and hippocampal volume.
Authors
- Christina S. Dintica (ORCID: https://orcid.org/0000-0001-8186-8140)
- Lenore J. Launer (ORCID: https://orcid.org/0000-0002-3238-7612)
- Xiaqing Jiang (ORCID: https://orcid.org/0000-0003-3633-0688)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- R. Nick Bryan (ORCID: https://orcid.org/0000-0002-2327-4579)
Institutions
- National Institutes of Health (US)
- University of California, San Francisco (US)
- Hospital of the University of Pennsylvania (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14464
- Citations
- 7
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Alzheimer's Association
- National Institute on Aging
- National Heart, Lung, and Blood Institute