Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis
Reduced levels of the autophagy protein p62 (SQSTM1) differentiated Lewy body dementias from Alzheimer's disease (AD) across multiple brain regions. Dementia with Lewy bodies (DLB) was distinguished from both AD and Parkinson's disease dementia (PDD) by altered TRIM33 and cysteine/glutamate transporter (SLC7A11) levels across brain regions. Key mitochondrial oxidative phosphorylation proteins (e.g., COX7A2, TOMM40L, NDUFV1), and synaptic proteins (e.g., GABRB3, GABRB2, GLUA3, GLUA4, SNAP47, dynamin1) were more abundant in preserved cognitive states. Extracellular matrix proteins and members of the complement system (decorin, biglycan, C4A, C4B) showed a strong positive correlation with cognitive decline.
Authors
- Per Nilsson (ORCID: https://orcid.org/0000-0001-6450-0870)
- Clive Ballard (ORCID: https://orcid.org/0000-0003-0022-5632)
- Janne Lehtiö (ORCID: https://orcid.org/0000-0002-8100-9562)
- Paul T. Francis (ORCID: https://orcid.org/0000-0001-8159-4469)
- Dag Aarsland (ORCID: https://orcid.org/0000-0001-6314-216X)
- Rui M. Branca (ORCID: https://orcid.org/0000-0003-3890-6476)
- Anna Canal-García (ORCID: https://orcid.org/0000-0001-7460-741X)
- Erika Bereczki (ORCID: https://orcid.org/0000-0002-0373-7417)
- Bengt Winblad (ORCID: https://orcid.org/0000-0002-0011-1179)
- Joana B. Pereira (ORCID: https://orcid.org/0000-0002-4604-2711)
Institutions
- King's College London (GB)
- University of Exeter (GB)
- Stavanger University Hospital (NO)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14375
- Citations
- 11
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.59
Funders
- Gun och Bertil Stohnes Stiftelse
- Loo och Hans Ostermans Stiftelse för Medicinsk Forskning
- Stiftelsen för Gamla Tjänarinnor
- Magnus Bergvalls Stiftelse
- Stiftelsen Längmanska Kulturfonden
- Demensfonden