Visible-Light-Induced Radical Carbon Oximation of Styrenes Using <i>N</i>-Nitrosoamine and Organic Halides
An efficient visible-light-induced radical carbon oximation of styrenes with 1-nitrosopyrrolidine and organic halides is developed. The reaction proceeds smoothly in the absence of a transition metal and a photocatalyst under mild conditions, producing a wide range of functionalized oximes in moderate to good yields. Mechanistic studies reveal that the reaction involves the generation of nucleophilic α-amino alkyl radicals and subsequent halogen atom transfer (XAT) with organic halides.
Authors
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-1583-7570)
- Jinping Lan
- Xiaolong Li (ORCID: https://orcid.org/0000-0001-8463-3646)
- Tao Wang (ORCID: https://orcid.org/0000-0002-4971-2020)
- Bin Zhang (ORCID: https://orcid.org/0000-0003-0542-1819)
- Mengyu Xu (ORCID: https://orcid.org/0000-0002-4215-5102)
- Jin Luo (ORCID: https://orcid.org/0000-0003-4001-1356)
Institutions
- Jiangxi Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1021/acs.joc.4c02193
- Citations
- 4
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.00
Funders
- National Natural Science Foundation of China
- Education Department of Jiangxi Province