Plasma Aβ <sub>42</sub> /Aβ <sub>40</sub> is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum
Lumipulse plasma amyloid beta (Aβ)<sub>42</sub>/Aβ<sub>40</sub> exhibited high accuracy in detecting amyloid positivity. Plasma amyloid-positive (Aβ+) individuals exhibited stability of Aβ<sub>42</sub>/Aβ<sub>40</sub> over time. Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub> predicted future cognitive decline across the Alzheimer's disease (AD) spectrum. Plasma Aβ<sub>42</sub>/Aβ<sub>40</sub> was sensitive to memory and tau burden in clinically unimpaired older adults.
Authors
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Robert R. Butler (ORCID: https://orcid.org/0000-0003-0200-8682)
- Nicole K. Corso (ORCID: https://orcid.org/0000-0002-8004-5617)
- America Romero
- Lü Tian (ORCID: https://orcid.org/0000-0002-5893-0169)
- Anthony D. Wagner (ORCID: https://orcid.org/0000-0003-0624-4543)
- Irina A. Skylar-Scott
- Frank M. Longo (ORCID: https://orcid.org/0000-0002-9514-7325)
- Kyan Younes (ORCID: https://orcid.org/0000-0002-9912-1616)
- Geoffrey A. Kerchner (ORCID: https://orcid.org/0000-0001-7674-0695)
- Guido Davidzon (ORCID: https://orcid.org/0000-0001-5579-6825)
- Carolyn Fredericks (ORCID: https://orcid.org/0000-0002-7051-6382)
- Javier Ramos Benitez (ORCID: https://orcid.org/0000-0001-8893-0146)
- Tony Wyss‐Coray (ORCID: https://orcid.org/0000-0001-5893-0831)
- Katrin I. Andreasson (ORCID: https://orcid.org/0000-0001-8391-4155)
- Igor Feinstein
- Maya Yutsis
- Edward Norman Wilson (ORCID: https://orcid.org/0000-0003-0640-5247)
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Divya Channappa
- Sharon J. Sha (ORCID: https://orcid.org/0000-0002-3666-1463)
- Gayle K. Deutsch (ORCID: https://orcid.org/0000-0001-6886-4356)
- Jaime Mendiola (ORCID: https://orcid.org/0000-0002-0657-9346)
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Alexandra N. Trelle (ORCID: https://orcid.org/0000-0003-2837-8753)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Marian Shahid (ORCID: https://orcid.org/0000-0002-8515-3238)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Victor W. Henderson (ORCID: https://orcid.org/0000-0003-1198-9240)
- Hillary Vossler
- Amanda Smith (ORCID: https://orcid.org/0000-0002-8714-1425)
- Jennifer Park
- Michelle S. Swarovski
- Kelly Chau
Institutions
- Roche (Switzerland) (CH)
- Neurosciences Institute (US)
- Yale University (US)
- Stanford Health Care (US)
- Stanford Medicine (US)
- University Radiology (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/alz.14442
- Citations
- 24
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.84
Funders
- Alzheimer's Association
- Jean Perkins Foundation
- National Institutes of Health
- National Institute on Aging