Cyclosporine A Delays the Terminal Disease Stage in the <i>Tfam</i><scp>KO</scp> Mitochondrial Myopathy Mouse Model Without Improving Mitochondrial Energy Production
The results do not support improved mitochondrial energy production as a mechanism underlying the prolonged lifespan of Tfam KO mitochondrial myopathy mice treated with CsA. Thus, other mechanisms must be involved, such as the previously observed CsA-mediated protection against excessive mitochondrial Ca<sup>2+</sup> accumulation.
Authors
- Charlotte Gineste (ORCID: https://orcid.org/0000-0001-8515-089X)
- David Bendahan (ORCID: https://orcid.org/0000-0002-1502-0958)
- Isabelle Varlet (ORCID: https://orcid.org/0000-0002-1711-7980)
- Julien Gondin (ORCID: https://orcid.org/0000-0002-3108-605X)
- Håkan Westerblad (ORCID: https://orcid.org/0000-0002-8180-3029)
- Augustin C. Ogier (ORCID: https://orcid.org/0000-0001-9178-9964)
- Émilie Pecchi
- Monique Bernard (ORCID: https://orcid.org/0000-0002-3179-8698)
- Benjamin Chatel (ORCID: https://orcid.org/0000-0002-8197-1903)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Toulon (FR)
- Inserm (FR)
- Karolinska Institutet (SE)
- Institut NeuroMyoGène (FR)
- Centre de Résonance Magnétique Biologique et Médicale (FR)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/mus.28315
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- French Muscular Dystrophy Association
- Agence Nationale de la Recherche