VGLL fusions define a new class of intraparenchymal central nervous system schwannoma

We identify and define a new benign tumor class, designated VGLL-altered intraparenchymal CNS schwannomas. These tumors feature VGLL alterations and a specific DNA-methylation profile, with schwannoma-like histopathology and CNS localization, akin to previously classified intracerebral schwannomas.

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Publication Details

Journal
Neuro-Oncology
Published
2024-12-23
DOI
https://doi.org/10.1093/neuonc/noae269
Citations
11
Primary Topic
Neurofibromatosis and Schwannoma Cases
Type
article
Field-Weighted Citation Impact
4.06
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article

VGLL fusions define a new class of intraparenchymal central nervous system schwannoma

Sebastian Brandner, Christian Johannes Hartmann, Ilon Liu, Michèle Simon et al.
11 citations
Neuro-Oncology
Neurofibromatosis and Schwannoma Cases
4.06
article

VGLL fusions define a new class of intraparenchymal central nervous system schwannoma

Sebastian Brandner, Christian Johannes Hartmann, Ilon Liu, Michèle Simon, Ashwyn A Perera, Viktor Zherebitskiy, Francesca Gianno, Sabrina Zechel, Martin Hasselblatt, Lorraina Robinson, Yelena Wilson, Pablo Hernáiz Driever, Bastiaan B.J. Tops, Sridhar Epari, Felix Behling, Christine Stadelmann, Andrey Korshunov, David Capper, Kanish Mirchia, Jens Schittenhelm, Simon Paine, Christin Siewert, Roland Coras, Eelco W. Hoving, Pieter Wesseling, Simone Schmid, Pauline C. Göller, Arie Perry, Kenneth Aldape, Felix Sahm, Matija Snuderl, Vassil Kaimaktchiev, Anna Tietze, David Jones, Arend Koch, G Lucas Calixto-Hope, Jakob Nückles
article en
11 citations

Abstract

We identify and define a new benign tumor class, designated VGLL-altered intraparenchymal CNS schwannomas. These tumors feature VGLL alterations and a specific DNA-methylation profile, with schwannoma-like histopathology and CNS localization, akin to previously classified intracerebral schwannomas.

Neuro-OncologyVol. 27(4)
Nottingham University Hospitals NHS Trust (GB), University of Nottingham (GB), Johns Hopkins University (US), German Cancer Research Center (DE), University of California, San Francisco (US), Homi Bhabha National Institute (IN), University of Utah (US), Heidelberg University (DE), Johns Hopkins Medicine (US), Tata Memorial Hospital (IN), Columbia Gorge Community College (US), University Hospital Heidelberg (DE), University of Saskatchewan (CA), Medizinische Hochschule Hannover (DE), Humboldt-Universität zu Berlin (DE), German Center for Pediatric and Adolescent Rheumatology (DE), NYU Langone Health (US), Universitätsklinikum Erlangen (DE), Akron Children's Hospital (US), Brain Tumour Research (GB), Center for Neuro-Oncology (US), University Hospital Münster (DE), National Center for Tumor Diseases (DE), Hopp Children's Cancer Center Heidelberg (DE), University Children's Hospital Tübingen (DE), Princess Máxima Center (NL), Bernstein Center for Computational Neuroscience Tübingen (DE), Queen's Medical Centre (GB), National Cancer Institute (US), SickKids Foundation (CA), Hertie Institute for Clinical Brain Research (DE), ERN GUARD-Heart (NL), National Hospital for Neurology and Neurosurgery (GB), Amsterdam University Medical Centers (NL), Neurological Surgery (US), Hood Technology (United States) (US), Memorial Hospital (US), University College London (GB), New York University (US), University of Göttingen (DE), Freie Universität Berlin (DE), Charité - Universitätsmedizin Berlin (DE), University of Tübingen (DE), Heidelberg University (US), Sapienza University of Rome (IT)
Good health and well-being
Openalex Percentile: Top 5%
Neurofibromatosis and Schwannoma Cases
4.06
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