VGLL fusions define a new class of intraparenchymal central nervous system schwannoma
We identify and define a new benign tumor class, designated VGLL-altered intraparenchymal CNS schwannomas. These tumors feature VGLL alterations and a specific DNA-methylation profile, with schwannoma-like histopathology and CNS localization, akin to previously classified intracerebral schwannomas.
Authors
- Sebastian Brandner (ORCID: https://orcid.org/0000-0002-9821-0342)
- Christian Johannes Hartmann (ORCID: https://orcid.org/0009-0004-3700-3536)
- Ilon Liu (ORCID: https://orcid.org/0000-0002-6186-3630)
- Michèle Simon (ORCID: https://orcid.org/0000-0001-9094-3632)
- Ashwyn A Perera
- Viktor Zherebitskiy
- Francesca Gianno (ORCID: https://orcid.org/0000-0002-6223-9952)
- Sabrina Zechel (ORCID: https://orcid.org/0000-0001-5385-2766)
- Martin Hasselblatt (ORCID: https://orcid.org/0000-0003-2707-8484)
- Lorraina Robinson (ORCID: https://orcid.org/0009-0005-1098-4909)
- Yelena Wilson (ORCID: https://orcid.org/0000-0003-1725-0041)
- Pablo Hernáiz Driever (ORCID: https://orcid.org/0000-0003-3135-3872)
- Bastiaan B.J. Tops (ORCID: https://orcid.org/0000-0002-1699-8210)
- Sridhar Epari (ORCID: https://orcid.org/0000-0002-1038-5755)
- Felix Behling (ORCID: https://orcid.org/0000-0002-1083-1276)
- Christine Stadelmann (ORCID: https://orcid.org/0000-0003-1766-5458)
- Andrey Korshunov (ORCID: https://orcid.org/0000-0002-5257-3623)
- David Capper (ORCID: https://orcid.org/0000-0003-1945-497X)
- Kanish Mirchia (ORCID: https://orcid.org/0000-0002-7371-7059)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Simon Paine (ORCID: https://orcid.org/0000-0002-1434-3931)
- Christin Siewert (ORCID: https://orcid.org/0000-0002-7625-6569)
- Roland Coras (ORCID: https://orcid.org/0000-0001-8617-0913)
- Eelco W. Hoving (ORCID: https://orcid.org/0000-0002-5587-0439)
- Pieter Wesseling (ORCID: https://orcid.org/0000-0001-5453-5201)
- Simone Schmid (ORCID: https://orcid.org/0000-0002-5787-7343)
- Pauline C. Göller (ORCID: https://orcid.org/0009-0007-2909-1611)
- Arie Perry (ORCID: https://orcid.org/0000-0002-8300-7261)
- Kenneth Aldape (ORCID: https://orcid.org/0000-0001-5119-7550)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Matija Snuderl (ORCID: https://orcid.org/0000-0003-0752-0917)
- Vassil Kaimaktchiev
- Anna Tietze (ORCID: https://orcid.org/0000-0002-2601-9055)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Arend Koch (ORCID: https://orcid.org/0000-0001-8589-4688)
- G Lucas Calixto-Hope
- Jakob Nückles
Institutions
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Johns Hopkins University (US)
- German Cancer Research Center (DE)
- University of California, San Francisco (US)
- Homi Bhabha National Institute (IN)
- University of Utah (US)
- Heidelberg University (DE)
- Johns Hopkins Medicine (US)
- Tata Memorial Hospital (IN)
- Columbia Gorge Community College (US)
- University Hospital Heidelberg (DE)
- University of Saskatchewan (CA)
- Medizinische Hochschule Hannover (DE)
- Humboldt-Universität zu Berlin (DE)
- German Center for Pediatric and Adolescent Rheumatology (DE)
- NYU Langone Health (US)
- Universitätsklinikum Erlangen (DE)
- Akron Children's Hospital (US)
- Brain Tumour Research (GB)
- Center for Neuro-Oncology (US)
- University Hospital Münster (DE)
- National Center for Tumor Diseases (DE)
- Hopp Children's Cancer Center Heidelberg (DE)
- University Children's Hospital Tübingen (DE)
- Princess Máxima Center (NL)
- Bernstein Center for Computational Neuroscience Tübingen (DE)
- Queen's Medical Centre (GB)
- National Cancer Institute (US)
- SickKids Foundation (CA)
- Hertie Institute for Clinical Brain Research (DE)
- ERN GUARD-Heart (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Neurological Surgery (US)
- Hood Technology (United States) (US)
- Memorial Hospital (US)
- University College London (GB)
- New York University (US)
- University of Göttingen (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Heidelberg University (US)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/neuonc/noae269
- Citations
- 11
- Primary Topic
- Neurofibromatosis and Schwannoma Cases
- Type
- article
- Field-Weighted Citation Impact
- 4.06