Comprehensive Analysis Reveals No Significant Correlation Between p16/<scp><i>CDKN2A</i></scp> Expression and Treatment Outcomes in Laryngeal Squamous Cell Carcinoma
While this study observes trends suggesting that low p16 protein expression is associated with longer DFS and advanced TNM stage in laryngeal cancer, the multivariate analysis did not establish p16 as an independent prognostic factor. These findings suggest that while p16 may have a biological role in tumor progression, its utility as a standalone prognostic marker in clinical outcomes requires further validation.
Authors
- Matthew E. Witek (ORCID: https://orcid.org/0000-0003-0570-3293)
- Ashley Cellini
- John C. Papadimitriou (ORCID: https://orcid.org/0000-0001-7963-5380)
- Ranee Mehra (ORCID: https://orcid.org/0000-0003-2477-9584)
- Daria A. Gaykalova (ORCID: https://orcid.org/0000-0001-5037-0147)
- Helen Nguyễn (ORCID: https://orcid.org/0000-0001-8015-5296)
- Ishita Gupta (ORCID: https://orcid.org/0000-0002-8627-3186)
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Georgetown University (US)
- MedStar Georgetown University Hospital (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- Head & Neck
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/hed.28044
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Cancer Society