Prediction of lacosamide concentrations to support dose optimization during pregnancy
Simulated changes in lacosamide concentration align with the limited data available in observational studies. Our simulations support the use of therapeutic drug monitoring and dose adjustments to maintain the efficacy of lacosamide pharmacotherapy.
Authors
- Angela K. Birnbaum (ORCID: https://orcid.org/0000-0002-3969-4906)
- Kimford J. Meador (ORCID: https://orcid.org/0000-0002-7471-882X)
- Catherine M.T. Sherwin (ORCID: https://orcid.org/0000-0002-0844-3207)
- Jessica Barry (ORCID: https://orcid.org/0000-0002-4670-5650)
- Page B. Pennell (ORCID: https://orcid.org/0000-0003-0568-2795)
- Sílvia M. Illamola (ORCID: https://orcid.org/0000-0003-3245-1626)
Institutions
- University of Minnesota (US)
- University of Pittsburgh (US)
- The University of Western Australia (AU)
- Califia Bio (United States) (US)
- Stanford University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1111/epi.18184
- Citations
- 3
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.33
Funders
- University of Minnesota
- National Institutes of Health
- Clinical and Translational Science Institute, University of Minnesota
- National Institute of Neurological Disorders and Stroke
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development