Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus
In ET+, subtle increases in bradykinesia scores correlate with striatal dopaminergic dysfunction, while kinetic tremor asymmetry is associated with hemispheric DAT binding asymmetry. These findings support the concept of partial dopaminergic involvement in the pathophysiology of ET+.
Authors
- Filip Scheperjans (ORCID: https://orcid.org/0000-0001-9502-7131)
- Toni Ihalainen
- Elina Mäkinen (ORCID: https://orcid.org/0000-0001-7591-1990)
- Reeta Levo (ORCID: https://orcid.org/0000-0003-4481-1254)
- Tero J. Vahlberg (ORCID: https://orcid.org/0000-0002-4935-3056)
- Tuomas Mertsalmi (ORCID: https://orcid.org/0000-0003-1005-7812)
- Mikael Eklund (ORCID: https://orcid.org/0000-0002-1947-712X)
- Tommi Noponen
- Emma A. Honkanen (ORCID: https://orcid.org/0000-0003-3497-5706)
- Simo Nuuttila (ORCID: https://orcid.org/0000-0002-1749-7936)
- Juho Joutsa (ORCID: https://orcid.org/0000-0002-3457-9415)
- Kirsi Murtomäki (ORCID: https://orcid.org/0000-0001-5759-1911)
- Valtteri Kaasinen (ORCID: https://orcid.org/0000-0002-3446-7093)
- Elina Jaakkola (ORCID: https://orcid.org/0000-0002-8003-1346)
- A. L. Kuusela (ORCID: https://orcid.org/0009-0004-1203-7828)
Institutions
- University of Helsinki (FI)
- University of Turku (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Turku PET Centre (FI)
Publication Details
- Journal
- Movement Disorders Clinical Practice
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/mdc3.14317
- Citations
- 1
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.37
Funders
- Alkoholitutkimussäätiö
- Turun Yliopistollinen Keskussairaala