Increased White Matter Aerobic Glycolysis in Multiple Sclerosis
Increased white matter glycolysis is a prominent feature of cerebral metabolism in MS. It begins early in the disease course, increases with disease duration and is independent of microstructural evidence of inflammation in normal appearing white matter. Optimization of the metabolic environment may be an important component of therapies designed to reduce progressive disability. ANN NEUROL 2025;97:766-778.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Manu S. Goyal (ORCID: https://orcid.org/0000-0003-1970-4270)
- Amber R. Salter (ORCID: https://orcid.org/0000-0002-1088-110X)
- Matthew R. Brier (ORCID: https://orcid.org/0000-0001-5987-8705)
- Chunwei Ying (ORCID: https://orcid.org/0000-0003-1060-3289)
- Hongyu An (ORCID: https://orcid.org/0000-0001-6459-2269)
- Aakash Patel
- Robert T. Naismith (ORCID: https://orcid.org/0000-0003-0520-4283)
- Anne H. Cross (ORCID: https://orcid.org/0000-0003-0829-7569)
- Bradley Judge
- Yong Wang (ORCID: https://orcid.org/0000-0003-2507-8333)
- Qing Wang (ORCID: https://orcid.org/0000-0002-3882-6540)
Institutions
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/ana.27165
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- National Multiple Sclerosis Society
- Foundation for Barnes-Jewish Hospital
- Institute of Clinical and Translational Sciences
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences