Caryophylli Cortex Suppress PD-L1 Expression in Cancer Cells and Potentiates Anti-Tumor Immunity in a Humanized PD-1/PD-L1 Knock-In MC-38 Colon Cancer Mouse Model
These findings suggest that CC extract exerts a potent antitumor effect as an immune checkpoint blocker by inhibiting PD-L1 expression in cancer cells and disrupting the PD-1/PD-L1 interaction.
Authors
- Aeyung Kim (ORCID: https://orcid.org/0000-0002-3176-3671)
- Jung Ho Han
- Hwan‐Suck Chung (ORCID: https://orcid.org/0000-0002-5901-0217)
- Eun‐Ji Lee
Institutions
- Korea Institute of Oriental Medicine (KR)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3390/nu16244415
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- National Research Foundation
- Korea Institute of Oriental Medicine
- National Research Foundation of Korea