T Cell Responses to BA.2.86 and JN.1 SARS-CoV-2 Variants in Elderly Subjects
The XBB.1.5-containing vaccine induced lower CD4+ T cell responses against BA.2.86 in the elderly. CD4+ T cells from BNT16b2-vaccinated, COVID-19-naïve subjects recognized ancestral and BA.2.86 RBD strains while showing reduced responses to JN.1. These results emphasize the need for tailored vaccine strategies for emerging variants, particularly in vulnerable populations.
Authors
- Stefania Varchetta (ORCID: https://orcid.org/0000-0002-0289-2896)
- Greta Forlani (ORCID: https://orcid.org/0000-0003-1987-7761)
- Daniela Dalla Gasperina (ORCID: https://orcid.org/0000-0002-1187-6222)
- Dalila Mele (ORCID: https://orcid.org/0000-0002-5217-2766)
- Mario U. Mondelli (ORCID: https://orcid.org/0000-0003-1811-3153)
- Irene Segato (ORCID: https://orcid.org/0009-0007-7454-8756)
Institutions
- University of Insubria (IT)
- University of Pavia (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3390/vaccines12121451
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.78