A novel anxiety-associated SNP identified in LYNX2 (LYPD1) is associated with decreased protein binding to nicotinic acetylcholine receptors
A polymorphism in LYNX2, which codes for an inhibitory modulator of nicotinic acetylcholine receptors, has the potential to lead to sensitized nicotinic receptor activity in anxiety-related circuits. The LYNX2 protein has been shown to bind to multiple nicotinic acetylcholine receptor subtypes, including α4β2, α7, and α3β4 subtypes, each of which have been shown to be involved in affective behaviors. This work suggests that a subpopulation of individuals harboring a deleterious mutation in LYNX2 may predispose them to anxiety through abnormal nicotinic receptor control. In the future, this work may lead to the development of a biomarker for anxiety or a diagnostic tool for the early detection of individuals with susceptibility to anxiety.
Authors
- Talulla B. Palumbo
- Krystle J. McLaughlin (ORCID: https://orcid.org/0000-0003-4105-1042)
- Matthew Beatty (ORCID: https://orcid.org/0000-0003-3198-9264)
- Amanda DeGraaf
- K. Anderson (ORCID: https://orcid.org/0000-0002-1842-0383)
- Peter Rogu
- Wonpil Im (ORCID: https://orcid.org/0000-0001-5642-6041)
- Gabrielle M. Gracias
- Katie M. Hoffman
- Almut Hupbach (ORCID: https://orcid.org/0000-0001-9632-9422)
- Julie M. Miwa (ORCID: https://orcid.org/0000-0002-4418-3756)
- Wenpeng Cao (ORCID: https://orcid.org/0000-0002-7345-755X)
- Avani V. Pisapati
- Xiao Hui Zhang (ORCID: https://orcid.org/0000-0002-8778-595X)
- Mark A. Crenshaw
- Hui Sun Lee
- Ethan Fisher-Perez
Institutions
- Rutgers, The State University of New Jersey (US)
- Lehigh University (US)
- Johnson University (US)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3389/fnbeh.2024.1347543
- Citations
- 2
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Directorate for Biological Sciences