A mucus layer derived from porcine intestinal organoid air–liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2
We established the porcine intestinal organoid mucus monolayer as a novel and valuable model for confirming the pivotal role of the small intestinal mucus layer in combating pathogen invasion. In addition, our findings highlight the significance of sialic acid modification of Muc2 in blocking coronavirus infections. This discovery opens promising avenues for the development of tailor-made drugs aimed at preventing porcine enteric coronavirus invasion.
Authors
- Yifei Cai (ORCID: https://orcid.org/0000-0002-4389-2948)
- Chen Tan (ORCID: https://orcid.org/0000-0003-4622-4483)
- Yuguang Fu (ORCID: https://orcid.org/0000-0003-3204-7156)
- Luc Willems (ORCID: https://orcid.org/0000-0002-0563-2213)
- Yunhang Zhang (ORCID: https://orcid.org/0009-0006-9868-558X)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0002-7273-0358)
- Guangliang Liu (ORCID: https://orcid.org/0000-0001-8158-5749)
- Yang Li (ORCID: https://orcid.org/0000-0002-6065-4706)
- Ning Yang (ORCID: https://orcid.org/0000-0002-6014-9670)
Institutions
- University of Liège (BE)
- Xinjiang Agricultural University (CN)
- Lanzhou Veterinary Research Institute (CN)
- Animal Science Research Institute (CN)
- Hainan Provincial Academy of Agricultural Sciences (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Lanzhou University (CN)
- Wageningen University & Research (NL)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s12915-024-02094-7
- Citations
- 5
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- National Natural Science Foundation of China
- Chinese Academy of Agricultural Sciences
- Southwest University
- Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences