Selective modification of tetrahydrochromeno[2,3-d]pyrimidin-2-ones

The paper presents the results of the synthesis and characterisation of seven new tetrahydrochromeno[2,3-d]pyrimidin-2-ones derivatives obtained by selective modification of the hydroxyl group at the C-8 position. The authors successfully used alkylation and acetylation reactions to introduce substituents into the molecule. This resulted in a series of new heterocyclic compounds with yields up to 94 %. The authors characterised the obtained compounds by NMR spectroscopy (¹H and ¹³C) and mass spectrometry.