Gestational Exposure to Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Childhood
In this study, gestational exposure to NSAIDs was not associated with a substantial increase in the risk of childhood CKD when comparing between siblings. However, the findings underscore the need for caution when prescribing NSAIDs during pregnancy, particularly indomethacin and ketorolac in the first trimester, mefenamic acid and diclofenac in the second trimester, and ibuprofen in the third trimester, to ensure the safety of the offspring's kidneys.
Authors
- You‐Lin Tain (ORCID: https://orcid.org/0000-0002-7059-6407)
- Chien‐Ning Hsu (ORCID: https://orcid.org/0000-0001-7470-528X)
- Hsiao‐Ching Kuo (ORCID: https://orcid.org/0000-0002-0953-1487)
- Lung‐Chih Li (ORCID: https://orcid.org/0000-0002-1808-0083)
- Chiu-Ju Chen
Institutions
- Kaohsiung Medical University (TW)
- Chang Gung University (TW)
- Kaohsiung Chang Gung Memorial Hospital (TW)
Publication Details
- Journal
- JAMA Pediatrics
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1001/jamapediatrics.2024.4409
- Citations
- 15
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 8.14
Funders
- Chang Gung Medical Foundation
- Kaohsiung Medical University
- National Science and Technology Council
- Kaohsiung Chang Gung Memorial Hospital