Iron Catalyzed Radical Alkylation of Cyclic Ketimines with Olefins via Metal Hydride Atom Transfer
Abstract Here, we present an innovative approach to achieve Minisci‐type alkylation of cyclic N ‐ketimines, enabling access to a diverse range of valuable alkylated sulfonyl ketimines via iron hydride hydrogen atom transfer. More than 35 examples are shown with a wide range of substrates. Additionally, this system is easy to operate and can be efficiently scaled up. Mechanistic investigations revealed that the alkyl radical process involved and the air acts as the sole oxidant in this system.
Authors
- Xinyue Xu (ORCID: https://orcid.org/0009-0007-8154-2336)
- Xixi Hu (ORCID: https://orcid.org/0009-0008-0746-041X)
- Yijia Zhu
- Hui Liu
- Dong Liu (ORCID: https://orcid.org/0000-0002-4265-5545)
- Lizhi Zhang (ORCID: https://orcid.org/0000-0002-8036-7309)
- Yu Tian
- Ruizhi Sun (ORCID: https://orcid.org/0000-0002-1190-4705)
Institutions
- Shandong University of Technology (CN)
- University of California, Santa Barbara (US)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/adsc.202401430
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China