Reduced Intra- and Extracellular Circulating Postprandial Lysosomal Acid Lipase Activity in Patients with MASLD
Patients with MASLD have reduced LAL activity in blood and plasma both before and 4 h after a meal. In patients with MASLD, the physiological negative correlation between circulating LAL levels and postprandial hypertriglyceridemia is lost.
Authors
- Lorenzo M. Donini (ORCID: https://orcid.org/0000-0003-4692-4754)
- Flaminia Ferri (ORCID: https://orcid.org/0000-0001-8553-5589)
- Simona Parisse (ORCID: https://orcid.org/0000-0002-9953-009X)
- Stefano Ginanni Corradini (ORCID: https://orcid.org/0000-0002-0839-1961)
- Bruno P. Meloni (ORCID: https://orcid.org/0000-0003-0964-0648)
- Giulia d’Amati (ORCID: https://orcid.org/0000-0002-6959-691X)
- Lucio Gnessi (ORCID: https://orcid.org/0000-0001-8217-2372)
- Giulia Tozzi (ORCID: https://orcid.org/0000-0002-1745-2797)
- Esraa A. Salem (ORCID: https://orcid.org/0009-0002-4191-9825)
- Alice Sabbadini
- Elena Gangitano (ORCID: https://orcid.org/0000-0003-1044-2278)
- A. De Santis (ORCID: https://orcid.org/0000-0001-7338-9203)
- Eleonora Poggiogalle (ORCID: https://orcid.org/0000-0003-0862-5892)
- Anna Morrone
- Monica Mischitelli (ORCID: https://orcid.org/0000-0003-1865-4101)
Institutions
- Bambino Gesù Children's Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Metabolites
- Published
- 2024-12-23
- DOI
- https://doi.org/10.3390/metabo14120725
- Citations
- 2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- AstraZeneca
- Alexion Pharmaceuticals