Development and Evaluation of Non-Antibiotic Growth Promoters for Food Animals

The widespread utilization of antibiotic growth promoters (AGPs) boosts the growth rate of food animals and enhances human living standards. Nevertheless, it is accompanied by escalating antibiotic resistance. Consequently, there is an urgent demand to develop novel alternatives to growth promoters. The objective of this study was to develop a non-antibiotic growth promoter (NAGP) for augmenting the growth rate of food animals. The growth-promoting effect of plant-derived NAGPs was assessed in mice and broiler chickens, and its growth-promoting mechanism was initially investigated. The results reveal that a combination of hawthorn (also known as shanzha) and astragalus (also known as huangqi) extracts (SQ) enhanced the growth rate of mice both <i>in vivo</i> and <i>in vitro</i>, attributed to their significant capacity to promote muscle growth and improve immunity (<i>p</i> < 0.05). The composite super energy extract M (CSEE-M), further optimized on the basis of SQ, significantly improved growth performance and feed conversion ratio, and elevated the activity of intestinal digestive enzymes (<i>p</i> < 0.05) in both mice and broilers and reshaped the gut microbiota of broilers. The addition of 0.5% CSEE-M to broiler drinking water significantly increased muscle content and improved carcass quality (<i>p</i> < 0.05). In conclusion, both SQ and CSEE-M hold great promise as NAGPs and serve as effective substitutes to AGPs. This research not only furnishes new solutions for the misuse of antibiotics but presents a fresh perspective for the development of growth promoters.