Modification in ICU design may influence circadian serum cholinesterase activities: a proof-of-concept pilot study
Implementing a comprehensive set of changes to the design of ICU rooms, including a dynamic lighting system, may influence the course of the activity patterns of acetylcholinesterase and butyrylcholinesterase in critically ill patients. Modifications to environmental factors could potentially offer neuroprotective benefits and facilitate the realignment of circadian rhythms within the cholinergic system. Clinical trial registration ClinicalTrials.gov: NCT02143661. Registered May 21, 2014.
Authors
- Anika Mueller (ORCID: https://orcid.org/0000-0002-6859-7080)
- Claudia Spies (ORCID: https://orcid.org/0000-0002-1062-0495)
- Alawi Luetz (ORCID: https://orcid.org/0000-0001-8814-1809)
- Laura Hancke
- Maria Heinrich (ORCID: https://orcid.org/0000-0002-4530-7343)
- Klaus‐Dieter Wernecke (ORCID: https://orcid.org/0000-0002-3653-5520)
- Sebastian Schmidt (ORCID: https://orcid.org/0000-0002-1364-5436)
Institutions
- Humboldt-Universität zu Berlin (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Technische Universität Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1186/s40635-024-00709-5
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Pfizer
- Edwards Lifesciences
- Fresenius Medical Care North America
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Charité – Universitätsmedizin Berlin
- Deutsches Zentrum für Luft- und Raumfahrt
- Max-Planck-Gesellschaft
- Einstein Stiftung Berlin
- European Society of Anaesthesiology
- Stiftung Charité
- Gemeinsame Bundesausschuss
- Berlin Institute of Health
- CytoSorbents Europe
- AbbVie Deutschland