Enantioselective Synthesis of Isoindolinone by Sequential Palladium-Catalyzed Aza-Heck/Suzuki Coupling Reaction
We present a tandem aza-Heck/Suzuki cross-coupling reaction of <i>O</i>-phenyl hydroxamic ethers with readily available arylboronic and alkenyl boronic acids. This protocol is enabled by a palladium catalyst paired with chiral phosphoramidite ligands, particularly under mild reaction conditions, yielding efficient and succinct synthetic routes to chiral isoindolinones with high enantioselectivity. Furthermore, this reaction exhibits excellent functional group compatibility and a rich diversity of subsequent transformations.
Authors
- Shuaijie Wu
- Guodong Zhang (ORCID: https://orcid.org/0000-0003-4487-1820)
- Chao‐Guo Yan (ORCID: https://orcid.org/0000-0002-2777-9582)
- Wenyu Zhang (ORCID: https://orcid.org/0000-0002-1924-6591)
- Lei Wang (ORCID: https://orcid.org/0000-0002-8792-0234)
- Qing Wu (ORCID: https://orcid.org/0009-0003-4618-1580)
- Ying Han (ORCID: https://orcid.org/0000-0003-4622-6550)
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1021/acs.orglett.4c04239
- Citations
- 6
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province