Electrochemical Alkoxylation of Benzylic C(sp<sup>3</sup>)−H Bonds
Abstract We report an electrochemical process for the direct alkoxylation of benzylic C(sp 3 )−H bonds without the need for external oxidants or metal catalysts. This environmentally friendly and sustainable synthetic strategy facilitates the alkoxylation of C(sp 3 )−H in benzylic groups. The approach enables the late‐stage incorporation of complex alkoxy groups into bioactive molecules, providing potential applications in the synthesis of celestolide derivatives.
Authors
- Guoxue He (ORCID: https://orcid.org/0000-0001-9461-0982)
- Yu Zhou (ORCID: https://orcid.org/0000-0002-7684-2939)
- Naixuan Zhao
- Guojia Xie (ORCID: https://orcid.org/0000-0002-8250-6157)
- Shen-Chang Chang (ORCID: https://orcid.org/0000-0003-1746-9481)
- Zhenwei Zhang (ORCID: https://orcid.org/0000-0002-1308-3648)
- Miao Zheng
Institutions
- Shenyang Pharmaceutical University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Institute for Advanced Study (DE)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1002/ejoc.202401227
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.75