A Prospective Trial of Biomarker-Guided Surveillance for HPV-Positive Oropharynx Cancer Using Plasma Tumor Tissue–Modified Viral HPV DNA
TTMV-guided surveillance facilitates early detection of many HPV-positive oropharynx cancer recurrences, with the highest sensitivity for HPV16 and detectable pretreatment TTMV. Clinical implementation should be carefully informed by the limitations described in this study. See related commentary by Califano, p. 1561.
Authors
- Jeffrey P. Guenette (ORCID: https://orcid.org/0000-0002-4684-5469)
- Rosh K.V. Sethi (ORCID: https://orcid.org/0000-0002-1508-1363)
- Vickie Y. Jo (ORCID: https://orcid.org/0000-0003-4808-2714)
- Jonathan D. Schoenfeld (ORCID: https://orcid.org/0000-0002-5119-0401)
- Ravindra Uppaluri (ORCID: https://orcid.org/0000-0001-5988-6828)
- Laura A. Goguen (ORCID: https://orcid.org/0000-0001-8335-8566)
- Glenn J. Hanna (ORCID: https://orcid.org/0000-0002-9969-2523)
- Eleni Marie Rettig (ORCID: https://orcid.org/0000-0002-4715-0087)
- Donald J. Annino (ORCID: https://orcid.org/0000-0003-0525-0263)
- Kristine Wong (ORCID: https://orcid.org/0000-0003-4139-1581)
- B. Sargent
- Kartik Sehgal (ORCID: https://orcid.org/0000-0003-4391-6943)
- Roy B. Tishler (ORCID: https://orcid.org/0000-0002-0012-6055)
- Danielle N. Margalit (ORCID: https://orcid.org/0000-0002-8281-0829)
- Robert I. Haddad (ORCID: https://orcid.org/0000-0003-1413-0079)
- Edward S. Sim (ORCID: https://orcid.org/0000-0002-1632-286X)
- Evan Carey
- Janice Μ. Miller
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3053
- Citations
- 19
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 11.02