Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality
We identified a genetic lipid dysregulation signature characterized by seven lipid metabolism genes. Five genes in HYPO sepsis patients most strongly correlated with low CE, LPC, and SMs that mediate cholesterol storage and innate immunity.
Authors
- Charlotte Hopson (ORCID: https://orcid.org/0009-0003-5174-0543)
- Andrew Bertrand
- Dongyuan Wu (ORCID: https://orcid.org/0000-0001-9725-3239)
- Kiley Graim (ORCID: https://orcid.org/0000-0002-4569-8444)
- Susmita Datta (ORCID: https://orcid.org/0000-0002-7408-699X)
- Jordan A. Shavit (ORCID: https://orcid.org/0000-0002-2874-4904)
- Dawoud Sulaiman
- Faheem W. Guirgis (ORCID: https://orcid.org/0000-0002-4445-3939)
- Srinivasa T. Reddy (ORCID: https://orcid.org/0000-0003-2959-9531)
- Emilio B. Cagmat
- Vinitha Jacob (ORCID: https://orcid.org/0000-0002-3786-1520)
- Guillaume Labilloy
- Lauren Page Black (ORCID: https://orcid.org/0000-0001-6554-3207)
- Beulah Augustin
- Leslie Smith
- Daniel A. Hofmaenner
Institutions
- Northwestern University (US)
- University of California, Los Angeles (US)
- University of Michigan (US)
- University of Florida Health (US)
- University of Florida (US)
- University Hospital of Zurich (CH)
- Florida College (US)
Publication Details
- Journal
- Critical Care
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1186/s13054-024-05216-3
- Citations
- 3
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of General Medical Sciences